Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18344132 | 0.86 | HCRTR1 (0.33) | DPP4DPP8DPP7HCRTR1HCRTR2 | |
| SCHEMBL18344212 | 0.84 | CRBN (0.36) | DPP4DPP8DPP7HCRTR1HCRTR2 | |
| SCHEMBL18344078 | 0.84 | ELANE (0.44) | — | |
| SCHEMBL18344106 | 0.82 | ELANE (0.46) | — | |
| SCHEMBL18344180 | 0.81 | ELANE (0.47) | — | |
| SCHEMBL18344065 | 0.80 | HTR6 (0.39) | — | |
| SCHEMBL20296426 | 0.80 | HCRTR1 (0.54) | DPP4DPP8DPP7HCRTR1HCRTR2 | |
| SCHEMBL18344234 | 0.79 | LMNA (0.42) | — | |
| SCHEMBL18344040 | 0.77 | HCRTR1 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL18344101 | 0.76 | MGLL (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310767-A1 | NADPH OXIDASE 4 INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016207785-A1 | NADPH OXIDASE 4 INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-12-29 | — | — | WO | disclosed |