Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 4/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | FABP2 | P12104 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29814908 | 1.00 | CLCN2 (0.47) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL109811 | 0.84 | CLCN2 (0.49) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL4670497 | 0.83 | TSHR (0.52) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL7924637 | 0.83 | TSHR (0.47) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL31335879 | 0.81 | CA1 (0.48) | CLCN2TTRNR4A1PTGS2CYP1A2 | |
| SCHEMBL2496346 | 0.81 | CYP1A2 (0.41) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL9685948 | 0.81 | CLCN2 (0.46) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL6238744 | 0.81 | CYP1A2 (0.41) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL28942795 | 0.81 | CLCN2 (0.47) | CLCN2TTRNR4A1MEN1ADORA3 | |
| SCHEMBL1398470 | 0.81 | CA1 (0.48) | CLCN2TTRNR4A1PTGS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4027995-B1 | HPK1 ANTAGONISTS AND USES THEREOF | NIMBUS SATURN INC (US) | 2026-05-27 | — | — | EP | disclosed |
| US-12215105-B2 | HPK1 antagonists and uses thereof | Nimbus Saturn, Inc. (US) | 2025-02-04 | — | — | US | disclosed |
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | SCHRÖDINGER, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | SCHRÖDINGER, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | SCHRÖDINGER, INC. | 2024-01-25 | — | — | US | disclosed |
| US-11548890-B1 | HPK1 antagonists and uses thereof | Nimbus Saturn, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| US-11548890-B1 | HPK1 antagonists and uses thereof | Nimbus Saturn, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| CN-114945366-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2022-08-26 | — | — | CN | disclosed |
| EP-4027995-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-07-20 | — | — | EP | disclosed |
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-08-03 | — | — | US | disclosed |
| US-7754742-B2 | Imidazole carboxamides | ELI LILLY AND COMPANY (US) | 2010-07-13 | — | — | US | disclosed |
| WO-2010009062-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |
| US-20100016373-A1 | IMIDAZOLE CARBOXAMIDES | ELI LILLY AND COMPANY | 2010-01-21 | — | — | US | disclosed |
| US-20060293264-A1 | STAT3 decoy oligonucleotides and uses therefor | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-12-28 | — | — | US | disclosed |
| WO-2006012625-A2 | STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-02-02 | — | — | WO | disclosed |
| WO-2001083420-A2 | METHOD OF MAKING SUBSTITUTED DIHALO AROMATIC ACID CHLORIDES | OCCIDENTAL CHEMICAL CORPORATION (US) | 2001-11-08 | — | — | WO | disclosed |
| US-6225514-B1 | A MIXTURE OF AN AROMATIC HYDROCARBON, ESTER, NITRILE OR HALOGENATED AROMATIC, A HALOGENATING AGENT AND A STABLE ACID,AND CORROSION RESISTANT, HETEROGENEOUS, SOLID ACID CATALYST OF ?DOPED? MIXED OXIDES; BY-PRODUCT INHIBITION | OCCIDENTAL CHEMICAL CORPORATION | 2001-05-01 | — | — | US | disclosed |
| US-6211399-B1 | AROMATIC COMPOUND IS REACTED WITH A CHLORINATING AGENT OR A BROMINATING AGENT IN THE PRESENCE OF ABOUT 0.1 TO ABOUT 10 MOLE % OF A LEWIS ACID CATALYST AT A TEMPERATURE OF AMBIENT TO ABOUT 100 DEGREES C AND A PRESSURE OF 10 TO 100 PSI | OCCIDENTAL CHEMICAL CORPORATION | 2001-04-03 | — | — | US | disclosed |
| US-6124512-A | HETEROGENEOUS CATALYST. | OCCIDENTAL CHEMICAL CORPORATION (US) | 2000-09-26 | — | — | US | disclosed |
| US-6118018-A | Chlorination and bromination of aromatic compounds at atmospheric pressure | OCCIDENTAL CHEMICAL CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548890-B1 | HPK1 antagonists and uses thereof | PDXK, HIPK1, PCK1 | CLCN2 1877/4885TTR 4755/4885NR4A1 4499/4885 |
| US-20100016373-A1 | IMIDAZOLE CARBOXAMIDES | CYP3A4, CYP2C9, AADAC | CLCN2 1822/4885TTR 3561/4885NR4A1 3007/4885 |
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | CLCN2 1877/4885TTR 4755/4885NR4A1 4499/4885 |
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, PDXK, IP6K1 | CLCN2 1632/4885TTR 4597/4885NR4A1 2846/4885 |
| US-12215105-B2 | HPK1 antagonists and uses thereof | PDXK, HIPK1, PCK1 | CLCN2 1877/4885TTR 4755/4885NR4A1 4499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.