Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12846718 | 0.84 | HPGD (0.71) | HPGDALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL697213 | 0.79 | HPGD (0.54) | HPGDALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL16089692 | 0.77 | MAPK1 (0.73) | ALDH1A1LMNANPC1ALOX15 | |
| SCHEMBL18351760 | 0.77 | HPGD (0.51) | HPGDALDH1A1LMNAHTTNAMPT | |
| SCHEMBL8013063 | 0.76 | NOTUM (0.63) | HPGDALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL12569373 | 0.74 | HPGD (0.64) | HPGDALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL8240427 | 0.74 | PDE4B (0.57) | HPGDALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL14238822 | 0.73 | HPGD (0.83) | HPGDALDH1A1HTTL3MBTL1GABRD | |
| SCHEMBL7130857 | 0.73 | HPGD (0.83) | HPGDALDH1A1HTTL3MBTL1GABRD | |
| SCHEMBL17320467 | 0.73 | HPGD (0.71) | HPGDALDH1A1HTTL3MBTL1GABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533989-B2 | Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors | Ziarco Pharma Ltd. (GB) | 2017-01-03 | — | — | US | disclosed |