Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | FOS | P01100 | 1/20 | 0.34 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18352017 | 0.83 | SYK (0.45) | MAPTLMNASYKJAK3JAK1 | |
| SCHEMBL12106816 | 0.81 | MAPT (0.41) | MAPTLMNASYKHTTMAPK1 | |
| SCHEMBL18351993 | 0.81 | SYK (0.42) | MAPTLMNASYKJAK3JAK1 | |
| SCHEMBL18351982 | 0.81 | SYK (0.48) | MAPTLMNASYKHTTMAPK1 | |
| SCHEMBL12106915 | 0.80 | TP53 (0.40) | MAPTLMNASYKHTTMAPK1 | |
| SCHEMBL12103419 | 0.79 | MAPT (0.39) | MAPTLMNASYKHTTMAPK1 | |
| SCHEMBL18352139 | 0.79 | DGAT1 (0.40) | MAPTLMNASYKJAK3JAK1 | |
| SCHEMBL12103798 | 0.78 | TP53 (0.39) | MAPTLMNASYKHTTMAPK1 | |
| SCHEMBL12103452 | 0.77 | TP53 (0.51) | MAPTLMNASYKHTTMAPK1 | |
| SCHEMBL27892477 | 0.76 | MAPT (0.40) | MAPTLMNAHTTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533986-B2 | Bicyclic dihydropyridone kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-01-03 | — | — | US | disclosed |