Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18352518 | 0.95 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNASMN1; SMN2ZDHHC2 | |
| SCHEMBL18354901 | 0.92 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNASMN1; SMN2ZDHHC2 | |
| SCHEMBL18353003 | 0.87 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNASMN1; SMN2ZDHHC2 | |
| SCHEMBL18355349 | 0.84 | HCAR2 (0.49) | ALDH1A1KDM4ELMNASMN1; SMN2HCAR2 | |
| SCHEMBL18355259 | 0.84 | ATM (0.47) | ALDH1A1KDM4ELMNASMN1; SMN2HCAR2 | |
| SCHEMBL18352681 | 0.81 | ATM (0.50) | ALDH1A1KDM4ELMNASMN1; SMN2HCAR2 | |
| SCHEMBL18364466 | 0.80 | NPY5R (0.46) | ALDH1A1KDM4ELMNASMN1; SMN2ACHE | |
| SCHEMBL18364404 | 0.78 | MAPT (0.48) | ALDH1A1KDM4ELMNASMN1; SMN2HCAR2 | |
| SCHEMBL18353023 | 0.78 | HCAR2 (0.54) | ALDH1A1KDM4ELMNAHCAR2MAPT | |
| SCHEMBL18355254 | 0.77 | ZDHHC2 (0.51) | ZDHHC2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170001953-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-01-05 | — | — | US | disclosed |
| US-20170001953-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001953-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | FH, FPGS, APC | ALDH1A1 1949/4885KDM4E 3556/4885LMNA 4358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.