Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.55 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 5/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361608 | 0.82 | IDO1 (0.60) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL21566711 | 0.76 | IDO1 (0.60) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL10192319 | 0.74 | IDO1 (0.54) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL12355661 | 0.73 | CA12 (0.39) | HTR6HTR1AHTR7HTR2CHTR2A | |
| SCHEMBL20646497 | 0.73 | IDO1 (0.66) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL31326499 | 0.71 | IDO1 (1.00) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL3710027 | 0.69 | HTR2C (0.61) | IDO1HPGDSLDLRPCSK9BDKRB2 | |
| SCHEMBL15577030 | 0.69 | IDO1 (0.60) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL19732321 | 0.67 | IDO1 (0.57) | IDO1HPGDSLDLRPCSK9BDKRB2 | |
| SCHEMBL21128564 | 0.67 | IDO1 (0.57) | IDO1HPGDSLDLRPCSK9HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170001990-A1 | PIPERIDINE-DIONE DERIVATIVES | GENENTECH, INC. (US) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001990-A1 | PIPERIDINE-DIONE DERIVATIVES | DRD4, ADORA1, ADORA3 | IDO1 783/4885HPGDS 3691/4885GPBAR1 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.