Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760540 | 0.87 | ALDH1A1 (0.46) | RECQLALDH1A1MMP8TAAR1MAPT | |
| SCHEMBL606869 | 0.85 | ALDH1A1 (0.72) | RECQLALDH1A1MMP8TAAR1THRB | |
| SCHEMBL27574238 | 0.82 | ALDH1A1 (0.57) | RECQLALDH1A1MMP8LMNAMAPT | |
| SCHEMBL27993635 | 0.77 | MMP8 (0.69) | RECQLALDH1A1MMP8TAAR1THRB | |
| SCHEMBL5913849 | 0.76 | CYP3A4 (0.59) | RECQLALDH1A1MMP8TAAR1LMNA | |
| SCHEMBL10821760 | 0.76 | MMP8 (0.63) | RECQLALDH1A1MMP8TAAR1THRB | |
| SCHEMBL8710582 | 0.75 | MMP8 (0.79) | RECQLALDH1A1MMP8TAAR1THRB | |
| SCHEMBL1492859 | 0.75 | MMP8 (0.65) | RECQLALDH1A1MMP8TAAR1THRB | |
| SCHEMBL7271605 | 0.74 | MMP8 (0.57) | RECQLALDH1A1MMP8THRBLMNA | |
| SCHEMBL7271610 | 0.74 | MMP8 (0.57) | RECQLALDH1A1MMP8THRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102119153-A | Method for preparation of piperazindione derivates | BASF SE | 2011-07-06 | — | — | CN | disclosed |
| US-20110144336-A1 | Method for Preparation of Piperazindione Derivatives | BASF SE (DE) | 2011-06-16 | — | — | US | disclosed |
| EP-2318379-A1 | METHOD FOR PREPARATION OF PIPERAZINDIONE DERIVATES | BASF SE (DE) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010018067-A1 | METHOD FOR PREPARATION OF PIPERAZINDIONE DERIVATES | BASF SE (DE) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144336-A1 | Method for Preparation of Piperazindione Derivatives | H1-0, H1-3, H1-2 | RECQL 1157/4885ALDH1A1 705/4885MMP8 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.