Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18353141 | 0.94 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL18358057 | 0.93 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL18360944 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL18352552 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL14999228 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL18360960 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL18352687 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2LMNAPOLBTSHRL3MBTL1 | |
| SCHEMBL14999229 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL14180427 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAPOLBTSHRRECQL | |
| SCHEMBL296556 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAPOLBTSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170001952-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001952-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | FH, FPGS, APC | SMN1; SMN2 79/4885LMNA 4358/4885POLB 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.