Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27491392 | 0.98 | ALDH1A1 (0.65) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL21145087 | 0.93 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL6654790 | 0.93 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL28560793 | 0.91 | ALDH1A1 (0.75) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL2199115 | 0.91 | ALDH1A1 (0.75) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL1127711 | 0.91 | ALDH1A1 (0.75) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL28561743 | 0.89 | ALDH1A1 (0.65) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL21043934 | 0.89 | ALDH1A1 (0.65) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL17966762 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| Citric Acid SCHEMBL28654760 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200172835-A1 | DETERGENTS AND CLEANERS WITH IMPROVED CLEANING POWER THROUGH THE USE OF CARBOHYDRATES | HENKEL AG & CO. KGAA (DE) | 2020-06-04 | — | — | US | disclosed |
| US-9328220-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8992798-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-8784686-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2014-07-22 | — | — | US | disclosed |
| US-20140187684-A1 | LIQUIDS | INNOVIA FILMS LIMITED (GB) | 2014-07-03 | — | — | US | disclosed |
| CN-102491875-B | Distillation-free concentration method for alcohol | UNIV DONGHUA | 2014-02-26 | — | — | CN | disclosed |
| CN-102491875-A | Distillation-free concentration method for alcohol | UNIV DONGHUA | 2012-06-13 | — | — | CN | disclosed |
| US-20110257433-A1 | LIQUIDS | THE UNIVERSITY OF YORK (GB) | 2011-10-20 | — | — | US | disclosed |
| EP-2322497-A1 | Ionic liquids comprising nitrogen containing cations | Innovia Films Limited (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-20070251154-A1 | Lapping Composition and Method Using Same | LOMBARDI JOHN L | 2007-11-01 | — | — | US | disclosed |
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| WO-2005076871-A2 | LAPPING COMPOSITION AND METHOD USING SAME | LOMBARDI JOHN L (US) | 2005-08-25 | — | — | WO | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| CN-1234827-A | Cleaning compositions comprising mycodextranase | PROCTER & GAMBLE (US) | 1999-11-10 | — | — | CN | disclosed |
| US-H1632-H | MIXTURE OF ETHOXYLATED ALCOHOL, ALCOHOL ETHOXYSULFATE,ALKYLARYL SULFONATE, WATER AND BUILDERS | SHELL OIL COMPANY (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0077674-A2 | Viscous compositions containing amidobetaines and salts | UNILEVER PLC (GB) | 1983-04-27 | — | — | EP | disclosed |
| US-4375421-A | COSMETICS, CLEANING COMPOUNDS | LEVER BROTHERS COMPANY (US) | 1983-03-01 | — | — | US | disclosed |