Citric Acid

Citric Acid

SCHEMBL6654790

CC(C)N.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.39
ALDH1A1 P00352 2/20 0.71
KDM4E B2RXH2 3/20 0.45
TSHR P16473 2/20 0.45
MAPT P10636 2/20 0.45
LMNA P02545 2/20 0.45
ALOX15 P16050 1/20 0.45
HMGCR P04035 1/20 0.44
CHRM1 P11229 1/20 0.44
TBXA2R P21731 1/20 0.44
ADRA1A P35348 1/20 0.44
CYP2D6 P10635 2/20 0.42
CYP2C19 P33261 1/20 0.42
HIF1A Q16665 1/20 0.42
CPT2 P23786 1/20 0.40
ACLY P53396 1/20 0.40
SLC13A5 Q86YT5 4/20 0.40
GABRP O00591 2/20 0.39
GABRD O14764 2/20 0.39
GABRA1 P14867 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL21145087 1.00 ALDH1A1 (0.71) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL1835950 0.93 ALDH1A1 (0.68) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL27491392 0.91 ALDH1A1 (0.65) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL21043934 0.91 ALDH1A1 (0.65) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL28561743 0.91 ALDH1A1 (0.65) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL4741355 0.89 ALDH1A1 (0.62) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL2199115 0.88 ALDH1A1 (0.75) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL1127711 0.88 ALDH1A1 (0.75) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL28560793 0.88 ALDH1A1 (0.75) ALDH1A1KDM4ETSHRMAPTLMNA
Citric Acid SCHEMBL5874391 0.87 ALDH1A1 (0.83) ALDH1A1KDM4ETSHRMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200179254-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2020-06-11 US disclosed
US-20190240129-A1 CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2019-08-08 US disclosed
EP-3518878-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION Henkel AG & Co. KGaA (DE) 2019-08-07 EP disclosed
US-20190216714-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2019-07-18 US disclosed
US-20190216703-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2019-07-18 US disclosed
EP-0871685-B1 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER INT LLC (US) 2004-06-30 EP disclosed
EP-0871685-A4 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER INC (US) 2000-02-23 EP disclosed
EP-0871685-A1 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER, INC. (US) 1998-10-21 EP disclosed
WO-1998020088-A1 PREPARATION OF HYDROCARBON GELS FROM FERRIC SOURCES, POLYCARBOXYLIC ACID COMPOUNDS, AND OPTIONAL AMINES, IN COMBINATION WITH PHOSPHATE ESTERS CLEARWATER, INC. (US) 1998-05-14 WO disclosed
US-5693837-A SALT FORMATION BY REACTING FERRIC SULFATE, ALKYLAMINE AND CITRIC ACID; USED AS GELLING AGENTS COMBINED WITH ORTHOPHOSPHATE ESTER FOR HYDROCARBONS USED IN FRACTURING PETROLEUM PRODUCING FORMATIONS CLEARWATER, INC. (US) 1997-12-02 US disclosed
US-5647900-A HYDROCARBON FRACTURING LIQUID, PHOSPHATE, FERRIC IRON TO FORM GEL AND POLYCARBOXYLIC ACID OR SALTS THEN FRACTURING CLEARWATER, INC. (US) 1997-07-15 US disclosed
US-5571315-A INTRODUCING A MIXTURE OF A HYDROCARBON LIQUID, AN ORGANIC PHOSPHATE AND FERRIC AMMONIUM CITRATE OR A DERIVATIVE THEREOF INTO A FORMATION UNDER PRESSURE CLEARWATER, INC. (US) 1996-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190240129-A1 CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, CUTA, S100A10 MEN1 3369/4885ALDH1A1 1010/4885KDM4E 461/4885
US-20190216703-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, SRRM2, IK MEN1 4505/4885ALDH1A1 3629/4885KDM4E 1699/4885
US-20190216714-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, CD44, PCNA MEN1 2001/4885ALDH1A1 1465/4885KDM4E 251/4885
US-20200179254-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, CUTA, DSG1 MEN1 3038/4885ALDH1A1 1179/4885KDM4E 332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.