Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | ACLY | P53396 | 3/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28560793 | 1.00 | ALDH1A1 (0.75) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL28654760 | 0.98 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL17966762 | 0.98 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL6061242 | 0.95 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL27588805 | 0.91 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL1835950 | 0.91 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL27625289 | 0.91 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL653301 | 0.91 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL27797802 | 0.89 | ALDH1A1 (0.60) | ALDH1A1ACLYCPT2TSHRKDM4E | |
| Citric Acid SCHEMBL28220035 | 0.89 | ALDH1A1 (0.60) | ALDH1A1ACLYCPT2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110052256-A | It is a kind of for handling the adsorbent of heavy metal wastewater thereby | 襄阳先创环保科技有限公司 | 2019-07-26 | — | — | CN | claimed |
| CN-104975368-A | Multiwalled carbon nanotube and graphene reinforced modified regenerated protein fiber and preparation method thereof | UNIV TIANJIN POLYTECHNIC | 2015-10-14 | — | — | CN | claimed |
| US-20100323895-A1 | CLEANING, SANITISING AND STERILISING PREPARATIONS | ARCIS BIOTECHNOLOGY HOLDINGS LIMITED (GB) | 2010-12-23 | — | — | US | claimed |
| EP-2262883-A2 | CLEANING, SANITISING AND STERILISING PREPARATIONS | Altos Medical, LLC (US) | 2010-12-22 | — | — | EP | claimed |
| WO-2009117299-A2 | CLEANING, SANITISING AND STERILISING PREPARATIONS | ALTOS MEDICAL, LLC (US) | 2009-09-24 | — | — | WO | claimed |
| CN-119523912-A | Lithospermum erythrorhizon extract nano microcrystalline particles and self-microemulsion thereof, preparation method and application | 北京国医医联健康科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-116333016-A | Talarmycin impurity M and salt and preparation method thereof | 艾美科健（中国）生物医药有限公司 | 2023-06-27 | — | — | CN | disclosed |
| US-20230074804-A1 | PREPARATION OF SUFENTANIL CITRATE AND SUFENTANIL BASE | MALLINCKRODT ENTERPRISES LLC | 2023-03-09 | — | — | US | disclosed |
| US-20210061793-A1 | PREPARATION OF SUFENTANIL CITRATE AND SUFENTANIL BASE | VTESSE LLC | 2021-03-04 | — | — | US | disclosed |
| US-10899749-B2 | Preparation of sufentanil citrate and sufentanil base | SpecGx LLC (US) | 2021-01-26 | — | — | US | disclosed |
| US-20200197310-A1 | Technology for Preparation of Macromolecular Microspheres | NEXBIO, INC. | 2020-06-25 | — | — | US | disclosed |
| CN-107541186-B | Carbon nanotube film and ferrite composite wave-absorbing material and preparation method thereof | 天津师范大学 | 2020-04-10 | — | — | CN | disclosed |
| US-6270805-B1 | Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate | ANDRX PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | disclosed |
| WO-2000027370-A1 | CONTROLLED RELEASE FORMULATION FOR WATER SOLUBLE DRUGS | ANDRX PHARMACEUTICALS, INC. (US) | 2000-05-18 | — | — | WO | disclosed |
| EP-0159160-B1 | EBURNANE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-08-10 | — | — | EP | disclosed |
| EP-0043835-B1 | DENTURE CLEANING | DEN-MAT, INC. (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0159160-A1 | Eburnane derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-10-23 | — | — | EP | disclosed |
| EP-0043835-A4 | DENTURE CLEANING. | DEN MAT INC (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0043835-A1 | DENTURE CLEANING. | DEN MAT INC (US) | 1982-01-20 | — | — | EP | disclosed |
| WO-1981001969-A1 | DENTURE CLEANING | IBSEN R | 1981-07-23 | — | — | WO | disclosed |