Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | AGXT | P21549 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31416562 | 0.81 | RIPK1 (0.32) | RAB9APKMIDO1AGXTCES2 | |
| SCHEMBL14703761 | 0.81 | CES2 (0.38) | RAB9AALDH1A1IDO1AGXTCES2 | |
| SCHEMBL5306361 | 0.80 | PTGS2 (0.34) | MAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL39406 | 0.76 | CES2 (0.43) | POLBMAPTALDH1A1TDP1CES2 | |
| SCHEMBL29395656 | 0.76 | CES2 (0.43) | POLBMAPTALDH1A1TDP1CES2 | |
| SCHEMBL16976767 | 0.76 | IDO1 (0.41) | ALDH1A1TDP1IDO1AGXTCES2 | |
| SCHEMBL2318155 | 0.76 | CES2 (0.36) | ALDH1A1TDP1IDO1AGXTCES2 | |
| SCHEMBL21315979 | 0.73 | ORAI1 (0.48) | POLBMAPTRAB9AALDH1A1TDP1 | |
| SCHEMBL26576590 | 0.72 | CES2 (0.40) | POLBMAPTALDH1A1TDP1PKM | |
| SCHEMBL2407958 | 0.72 | ORAI1 (0.44) | ALDH1A1TDP1IDO1AGXTCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912702-B2 | Substituted pyridines as inhibitors of histone deacetylase | ALKERMES, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20210276977-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | ALKERMES, INC. | 2021-09-09 | — | — | US | disclosed |
| WO-2017001733-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2017-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912702-B2 | Substituted pyridines as inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC3 | POLB 1316/4885MAPT 975/4885RAB9A 3405/4885 |
| US-20210276977-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC2, HDAC11 | POLB 684/4885MAPT 1407/4885RAB9A 3189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.