Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 15/20 | 0.46 |
| ▸ | BRD2 | P25440 | 6/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6040649 | 0.91 | ERN1 (0.59) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL18359657 | 0.80 | KDM4E (0.57) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL19422785 | 0.79 | BRD4 (0.50) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL28446320 | 0.78 | BRD4 (0.52) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL16896770 | 0.77 | BRD4 (0.45) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL28435853 | 0.77 | KDM4E (0.55) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL20373759 | 0.76 | NR3C1 (0.46) | ERN1NR3C1BRD4BRD2BRD3 | |
| SCHEMBL24027942 | 0.76 | ALDH1A1 (0.43) | ERN1 | |
| SCHEMBL30212976 | 0.76 | ALDH1A1 (0.43) | ERN1 | |
| SCHEMBL16896803 | 0.76 | BRD4 (0.46) | ERN1NR3C1BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017001733-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2017-01-05 | — | — | WO | disclosed |