Calcifediol Anhydrous

Calcifediol Anhydrous

SCHEMBL1836573

C=C1CC[C@@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

VDR

The experimentally established mechanism targets of Calcifediol Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VDR known ✓ P11473 8/20 0.82
MAPT P10636 5/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
SREBF1 P36956 1/20 1.00
MEN1 O00255 3/20 0.82
KMT2A Q03164 3/20 0.82
ALDH1A1 P00352 2/20 0.82
CYP3A4 P08684 2/20 0.82
ALOX15 P16050 2/20 0.82
PGR P06401 2/20 0.82
ADORA3 P0DMS8 2/20 0.82
TDP1 Q9NUW8 1/20 0.82
CDC25A P30304 1/20 0.82
HSPD1 P10809 1/20 0.82
HPGD P15428 1/20 0.82
TBXA2R P21731 1/20 0.82
PTGS1 P23219 1/20 0.82
GLRA1 P23415 1/20 0.82
DRD3 P35462 1/20 0.82
HSPE1 P61604 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Calcifediol Anhydrous SCHEMBL10018928 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL13301741 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL9933434 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL3296 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL24102681 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL5614025 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL24051907 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL14112503 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL24571935 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1
Calcifediol Anhydrous SCHEMBL22403256 1.00 MAPT (1.00) MAPTSMN1; SMN2SREBF1VDRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3152185-B1 METHOD AND USAGE OF A SALT FOR SEPARATING EPIMERS BY ION MOBILITY SPECTROMETRY ROCHE DIAGNOSTICS GMBH (DE) 2023-10-04 EP claimed
CN-116482241-A Liquid chromatography-mass spectrometry combined method and kit for detecting metabolites of vitamin D 广州凯普医药科技有限公司 2023-07-25 CN claimed
WO-2008154574-A1 METHOD AND COMPOSITION FOR THE TREATMENT OF CARDIAC HYPERTROPHY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2008-12-18 WO claimed
US-20080305186-A1 Method and Composition for the Treatment of Cardiac Hypertrophy BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2008-12-11 US claimed
US-12459905-B2 Reagent for mass spectrometry ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2025-11-04 US disclosed
EP-4623304-A1 DERIVATISATION AGENT FOR LASER DESORPTION IONIZATION MASS SPECTROMETRY F. Hoffmann-La Roche AG (CH) 2025-10-01 EP disclosed
US-20250277801-A1 DERIVATISATION AGENT FOR LASER DESORPTION IONIZATION MASS SPECTROMETRY ROCHE DIAGNOSTICS OPERATIONS, INC. 2025-09-04 US disclosed
EP-2249842-B2 USE OF 25-HYDROXY-VITAMIN D3 AND VITAMIN D TO AFFECT HUMAN MUSCLE PHYSIOLOGY DSM IP ASSETS BV (NL) 2025-03-05 EP disclosed
US-20250064735-A1 CONTAINER SYSTEM AND PHARMACEUTICAL FOAM COMPOSITION COMPRISING BETAMETHASONE GLENMARK PHARMACEUTICALS LIMITED (IN) 2025-02-27 US disclosed
WO-2024110385-A1 DERIVATISATION AGENT FOR LASER DESORPTION IONIZATION MASS SPECTROMETRY F. HOFFMANN-LA ROCHE AG (CH) 2024-05-30 WO disclosed
US-20240092742-A1 REAGENT FOR MASS SPECTROMETRY ROCHE DIAGNOSTICS OPERATIONS, INC. 2024-03-21 US disclosed
US-11885818-B2 Reagent for mass spectrometry ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2024-01-30 US disclosed
US-20010036472-A1 Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings ENCINAL PHARMACEUTICAL INVESTMENTS, LLC 2001-11-01 US disclosed
EP-1140012-A2 CONVERSION OF LIQUID FILLED GELATIN CAPSULES INTO CONTROLLED RELEASE SYSTEMS BY MULTIPLE COATINGS Alza Corporation (US) 2001-10-10 EP disclosed
WO-2000038650-A1 GASTRIC RETENTION DOSAGE FORM HAVING MULTIPLE LAYERS ALZA CORPORATION (US) 2000-07-06 WO disclosed
WO-2000035419-A2 CONVERSION OF LIQUID FILLED GELATIN CAPSULES INTO CONTROLLED RELEASE SYSTEMS BY MULTIPLE COATINGS ALZA CORPORATION (US) 2000-06-22 WO disclosed
EP-0981615-A1 PROTEIN KINASE C INHIBITOR-LIKE PROTEIN (IPKC-2) INCYTE PHARMACEUTICALS, INC. (US) 2000-03-01 EP disclosed
US-6015678-A CONTACTING THE NUCLEIC ACIDS OF A SAMPLE WITH A NUCLEOTIDE SEQUENCE COMPLEMENTARY TO THE INHIBITOR, DETECTING HYBRIDIZATION; DIAGNOSIS OF CANCER, AUTOIMMUNE DISORDERS OR COGNITIVE DISORDERS INCYTE PHARMACEUTICALS, INC. (US) 2000-01-18 US disclosed
US-5922571-A HYBRIDIZED DETECTOR INCYTE PHARMACEUTICALS, INC. (US) 1999-07-13 US disclosed
WO-1998039444-A1 PROTEIN KINASE C INHIBITOR-LIKE PROTEIN (IPKC-2) INCYTE PHARMACEUTICALS, INC. (US) 1998-09-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12459905-B2 Reagent for mass spectrometry SRMS, PTMS, MMAB VDR 4478/4885MAPT 3790/4885SMN1; SMN2 1851/4885
US-20250064735-A1 CONTAINER SYSTEM AND PHARMACEUTICAL FOAM COMPOSITION COMPRISING BETAMETHASONE CYP24A1, CYP2R1, VDR VDR 3/4885MAPT 1367/4885SMN1; SMN2 4785/4885
US-20240092742-A1 REAGENT FOR MASS SPECTROMETRY SRMS, PTMS, MMAB VDR 4478/4885MAPT 3790/4885SMN1; SMN2 1851/4885
US-11885818-B2 Reagent for mass spectrometry SRMS, PTMS, MMAB VDR 4478/4885MAPT 3790/4885SMN1; SMN2 1851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.