Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366348 | 0.89 | ALDH1A1 (0.38) | ALDH1A1HPGDNPC1RAB9AKDM4E | |
| SCHEMBL23642485 | 0.76 | PSEN1 (0.38) | ALDH1A1HPGDNPC1RAB9AKDM4E | |
| SCHEMBL18372656 | 0.70 | RIPK1 (0.38) | ALDH1A1NPC1KDM4ETSHRBCHE | |
| SCHEMBL19659108 | 0.69 | RIPK1 (0.37) | ALDH1A1TSHRBCHETMEM97SIGMAR1 | |
| SCHEMBL15564257 | 0.69 | ALDH1A1 (0.34) | ALDH1A1LMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL23278661 | 0.67 | PDE4A (0.37) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL25097670 | 0.64 | LMNA (0.60) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL18372860 | 0.64 | HCAR2 (0.47) | NPC1RAB9AKMT2AGAA | |
| SCHEMBL30066529 | 0.63 | HTT (0.35) | ALDH1A1HPGDNPC1RAB9AKDM4E | |
| SCHEMBL1144663 | 0.63 | KDM4E (0.35) | ALDH1A1NPC1RAB9AKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008877-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008877-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | LSS, LPXN, CYP1B1 | ALDH1A1 1195/4885HPGD 2167/4885NPC1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.