Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CPB1 | P15086 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19589410 | 0.86 | KDM2B (0.49) | CDK5CDK5R1KDM2BKDM4AKDM5A | |
| SCHEMBL2327699 | 0.82 | CPB2 (0.47) | CDK5CDK5R1KDM2BKDM5ACPB2 | |
| SCHEMBL2331925 | 0.80 | CPB2 (0.45) | CDK5CDK5R1KDM2BKDM5ACPB2 | |
| SCHEMBL22920147 | 0.80 | CDK5 (0.50) | CDK5CDK5R1KDM4EPOLBALDH1A1 | |
| SCHEMBL28070514 | 0.79 | CPB2 (0.44) | CDK5CDK5R1KDM2BKDM5ACPB2 | |
| SCHEMBL6504137 | 0.79 | CPB2 (0.47) | CDK5CDK5R1KDM5ACPB2KMT2A | |
| SCHEMBL22702123 | 0.77 | KDM4E (0.50) | KDM2BKDM4EKMT2APKM | |
| SCHEMBL12985681 | 0.77 | CDK5 (0.48) | CDK5CDK5R1KDM2BKDM5ACPB2 | |
| SCHEMBL27869067 | 0.76 | CPB2 (0.40) | CDK5CDK5R1KDM2BKDM5ACPB2 | |
| Hydrochloric Acid SCHEMBL12985270 | 0.75 | CDK5 (0.47) | CDK5CDK5R1KDM2BKDM5ACPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
| US-9815818-B2 | Cot modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170008873-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | CDK5 88/4885CDK5R1 125/4885KDM2B 1774/4885 |
| US-20170008873-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | CDK5 88/4885CDK5R1 125/4885KDM2B 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.