Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.50 |
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837017 | 0.81 | KDR (0.53) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL32687974 | 0.80 | KDM4E (0.54) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL1834856 | 0.80 | ADORA3 (0.47) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL1660663 | 0.78 | NPC1 (0.56) | ALDH1A3ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL28958142 | 0.78 | NPC1 (0.56) | ALDH1A3ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL1659994 | 0.74 | KDM4E (0.52) | ALDH1A1NPC1RAB9AKDM4ERAD51 | |
| SCHEMBL1835084 | 0.74 | KDM5B (0.44) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL20602860 | 0.72 | ADORA3 (0.61) | KDM4EMAPT | |
| SCHEMBL8102213 | 0.72 | RAD51 (0.56) | ALDH1A3ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL15313405 | 0.71 | CYP19A1 (0.63) | GSK3BCDC7ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321314-B1 | SUBSTITUTED PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-05-31 | — | — | EP | claimed |
| US-9073915-B2 | Substituted pyrimidone derivatives | SANOFI (FR) | 2015-07-07 | — | — | US | claimed |
| US-20110144133-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | US | claimed |
| EP-2138493-A1 | Substituted pyrimidone derivatives | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | claimed |
| EP-2321314-B1 | SUBSTITUTED PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-05-31 | — | — | EP | disclosed |
| US-9073915-B2 | Substituted pyrimidone derivatives | SANOFI (FR) | 2015-07-07 | — | — | US | disclosed |
| US-20110144133-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | US | disclosed |
| EP-2321314-A2 | SUBSTITUTED PYRIMIDONE DERIVATIVES | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-05-18 | — | — | EP | disclosed |
| EP-2138493-A1 | Substituted pyrimidone derivatives | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2009156861-A2 | SUBSTITUTED PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144133-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVES | DHFR, TYMP, DPYD | GSK3B 4094/4885CDC7 1845/4885ROCK2 3186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.