SCHEMBL1837014

SCHEMBL1837014

O=C(O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1.O=C(O)N1CCC(n2c(=O)[nH]c3ncccc32)C[C@@H]1CCCN(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 11/20 0.48
TNKS O95271 1/20 0.44
PARP1 P09874 1/20 0.44
PARP2 Q9UGN5 1/20 0.44
OPRM1 P35372 1/20 0.42
OPRK1 P41145 1/20 0.42
OPRL1 P41146 1/20 0.42
BCHE P06276 1/20 0.42
ACHE P22303 1/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1834952 0.93 CALCRL (0.48) CALCRLTNKSPARP1PARP2
SCHEMBL1835272 0.89 OPRM1 (0.50) OPRM1OPRK1OPRL1BCHEACHE
SCHEMBL3403017 0.89 OPRM1 (0.50) OPRM1OPRK1OPRL1BCHEACHE
SCHEMBL1842968 0.89 CALCRL (0.44) CALCRLTNKSPARP1PARP2
SCHEMBL1837901 0.88 CHRM1 (0.49) OPRM1OPRK1OPRL1BCHEACHE
SCHEMBL1836672 0.88 OPRM1 (0.44) CALCRLTNKSPARP1PARP2OPRM1
SCHEMBL3666703 0.88 OPRM1 (0.51) OPRM1OPRK1OPRL1BCHEACHE
SCHEMBL1837876 0.88 OPRM1 (0.50) CALCRLOPRM1OPRK1OPRL1BCHE
SCHEMBL1834571 0.88 NPY5R (0.44) OPRM1OPRK1OPRL1BCHEACHE
SCHEMBL1838677 0.88 OPRM1 (0.46) CALCRLTNKSPARP1PARP2OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2160098-B9 USE OF COMPOUNDS HAVING A MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE INHIBITORY ACTIVITY AS HERBICIDE OR ALGAECIDE, HERBICIDE AND ALGAECIDE COMPOSITIONS COMMISSARIAT ENERGIE ATOMIQUE (FR) 2011-05-18 EP claimed
EP-2160098-B1 USE OF COMPOUNDS HAVING A MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE INHIBITORY ACTIVITY AS HERBICIDE OR ALGAECIDE, HERBICIDE AND ALGAECIDE COMPOSITIONS COMMISSARIAT ENERGIE ATOMIQUE (FR) 2010-11-10 EP claimed
EP-1997381-A1 Use of a compound having a monogalactosyldiacylglycerol synthase inhibitory activity as herbicide or algaecide, herbicide and algaecide compositions Commissariat à l'Energie Atomique (FR) 2008-12-03 EP claimed