SCHEMBL1842968

SCHEMBL1842968

O=C(O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1.O=C(O)N1CCC(n2c(=O)n(C(=O)c3ccccc3)c3ccccc32)C[C@@H]1CCCN(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 18/20 0.44
TNKS O95271 1/20 0.41
PARP1 P09874 1/20 0.41
PARP2 Q9UGN5 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1840373 0.97 CALCRL (0.42) CALCRLTNKSPARP1PARP2
SCHEMBL1837014 0.89 CALCRL (0.48) CALCRLTNKSPARP1PARP2
SCHEMBL1834952 0.88 CALCRL (0.48) CALCRLTNKSPARP1PARP2
SCHEMBL3799876 0.87 HSD11B1 (0.41) CALCRLPARP1
SCHEMBL3398375 0.86 CACNA1G (0.35)
SCHEMBL4730149 0.86 HSD11B1 (0.41) TNKSPARP1PARP2
SCHEMBL4737981 0.83 CACNA1G (0.33)
SCHEMBL4802852 0.81 HSD11B1 (0.41) CALCRL
SCHEMBL1839123 0.79 HSD11B1 (0.41) CALCRLPARP1
SCHEMBL3723955 0.78 CALCRL (0.40) CALCRLTNKSPARP1PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2160098-B9 USE OF COMPOUNDS HAVING A MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE INHIBITORY ACTIVITY AS HERBICIDE OR ALGAECIDE, HERBICIDE AND ALGAECIDE COMPOSITIONS COMMISSARIAT ENERGIE ATOMIQUE (FR) 2011-05-18 EP claimed
EP-2160098-B1 USE OF COMPOUNDS HAVING A MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE INHIBITORY ACTIVITY AS HERBICIDE OR ALGAECIDE, HERBICIDE AND ALGAECIDE COMPOSITIONS COMMISSARIAT ENERGIE ATOMIQUE (FR) 2010-11-10 EP claimed
EP-1997381-A1 Use of a compound having a monogalactosyldiacylglycerol synthase inhibitory activity as herbicide or algaecide, herbicide and algaecide compositions Commissariat à l'Energie Atomique (FR) 2008-12-03 EP claimed