SCHEMBL1834952

SCHEMBL1834952

O=C(O)N1CCC(n2c(=O)[nH]c3ncccc32)C[C@@H]1CCCN(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 17/20 0.48
TNKS O95271 1/20 0.45
PARP1 P09874 1/20 0.45
PARP2 Q9UGN5 1/20 0.45
DRD2 P14416 1/20 0.41
KCNH2 Q12809 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1837014 0.93 CALCRL (0.48) CALCRLTNKSPARP1PARP2
SCHEMBL1840373 0.91 CALCRL (0.42) CALCRLTNKSPARP1PARP2DRD2
SCHEMBL3723955 0.89 CALCRL (0.40) CALCRLTNKSPARP1PARP2DRD2
SCHEMBL1842968 0.88 CALCRL (0.44) CALCRLTNKSPARP1PARP2
SCHEMBL1834571 0.87 NPY5R (0.44) DRD2KCNH2
SCHEMBL3403017 0.87 OPRM1 (0.50) DRD2KCNH2
SCHEMBL1835272 0.87 OPRM1 (0.50) DRD2KCNH2
SCHEMBL1832648 0.86 OPRK1 (0.43) DRD2KCNH2
SCHEMBL1832267 0.86 OPRK1 (0.43) DRD2KCNH2
SCHEMBL1838176 0.83 OPRK1 (0.50) DRD2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2160098-B9 USE OF COMPOUNDS HAVING A MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE INHIBITORY ACTIVITY AS HERBICIDE OR ALGAECIDE, HERBICIDE AND ALGAECIDE COMPOSITIONS COMMISSARIAT ENERGIE ATOMIQUE (FR) 2011-05-18 EP claimed
EP-2160098-B1 USE OF COMPOUNDS HAVING A MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE INHIBITORY ACTIVITY AS HERBICIDE OR ALGAECIDE, HERBICIDE AND ALGAECIDE COMPOSITIONS COMMISSARIAT ENERGIE ATOMIQUE (FR) 2010-11-10 EP claimed