Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 3/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24026537 | 0.80 | IMPDH2 (0.43) | IMPDH2IMPDH1AAK1CYP3A4CYP2D6 | |
| SCHEMBL18378811 | 0.80 | LMNA (0.47) | LMNAPKMIMPDH2IMPDH1PDK2 | |
| SCHEMBL18367723 | 0.75 | LMNA (0.43) | LMNAPKMIMPDH2IMPDH1AAK1 | |
| SCHEMBL28680769 | 0.75 | ALDH1A1 (0.40) | MEN1KMT2A | |
| SCHEMBL19726598 | 0.74 | LMNA (0.42) | LMNAPKMIMPDH2IMPDH1PDK2 | |
| SCHEMBL26259988 | 0.73 | MEN1 (0.48) | LMNAPKMIMPDH2IMPDH1PDK2 | |
| SCHEMBL21163229 | 0.72 | CYP1A2 (0.47) | ADRA1ACYP2D6CYP19A1EDNRBEDNRA | |
| SCHEMBL22150409 | 0.72 | PDK2 (0.43) | LMNAPKMIMPDH2IMPDH1AAK1 | |
| SCHEMBL16371219 | 0.70 | IMPDH2 (0.60) | IMPDH2IMPDH1AAK1MAP4K4CYP19A1 | |
| SCHEMBL27976182 | 0.70 | AKR1B1 (0.44) | LMNAPKMIMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017007694-A1 | 6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS | GILEAD SCIENCES, INC. (US) | 2017-01-12 | — | — | WO | disclosed |