Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 5/20 | 0.48 |
| ▸ | CASP1 | P29466 | 5/20 | 0.48 |
| ▸ | CASP7 | P55210 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HBB | P68871 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TTK | P33981 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370862 | 1.00 | FGFR2 (0.48) | FGFR2CYP1A2CYP3A4MEN1USP2 | |
| SCHEMBL29368470 | 0.92 | TTK (0.47) | FGFR2CYP1A2CYP3A4MEN1USP2 | |
| SCHEMBL18376791 | 0.92 | TTK (0.47) | FGFR2CYP1A2CYP3A4MEN1USP2 | |
| SCHEMBL29370825 | 0.90 | FGFR2 (0.51) | FGFR2TTKFGFR1KDRJAK2 | |
| SCHEMBL18376788 | 0.90 | FGFR2 (0.58) | FGFR2TTKFGFR1KDRJAK2 | |
| SCHEMBL18376603 | 0.90 | FGFR2 (0.51) | FGFR2TTKFGFR1KDRJAK2 | |
| SCHEMBL18377065 | 0.88 | PTK2 (0.55) | FGFR2TTKFGFR1KDRJAK2 | |
| SCHEMBL29368482 | 0.88 | PTK2 (0.55) | FGFR2TTKFGFR1KDRJAK2 | |
| SCHEMBL29371334 | 0.87 | JAK2 (0.56) | CYP3A4TTKFGFR1KDRJAK2 | |
| SCHEMBL18376246 | 0.87 | JAK2 (0.56) | CYP3A4TTKFGFR1KDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |