Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 3/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376603 | 1.00 | FGFR2 (0.51) | FGFR2DRD2TTKPTK2FGFR1 | |
| SCHEMBL18376788 | 0.93 | FGFR2 (0.58) | FGFR2TTKPTK2FGFR1KDR | |
| SCHEMBL29368482 | 0.93 | PTK2 (0.55) | FGFR2TTKPTK2FGFR1KDR | |
| SCHEMBL18377065 | 0.93 | PTK2 (0.55) | FGFR2TTKPTK2FGFR1KDR | |
| SCHEMBL29371829 | 0.91 | FGFR2 (0.56) | FGFR2DRD2TTKPTK2JAK2 | |
| SCHEMBL18376648 | 0.91 | FGFR2 (0.56) | FGFR2DRD2TTKPTK2JAK2 | |
| SCHEMBL18376246 | 0.90 | JAK2 (0.56) | TTKPTK2FGFR1KDRJAK2 | |
| SCHEMBL29371334 | 0.90 | JAK2 (0.56) | TTKPTK2FGFR1KDRJAK2 | |
| SCHEMBL29370862 | 0.90 | FGFR2 (0.48) | FGFR2TTKPTK2FGFR1KDR | |
| SCHEMBL18376604 | 0.90 | FGFR2 (0.48) | FGFR2TTKPTK2FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |