Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 10/20 | 0.55 |
| ▸ | BRD4 | O60885 | 9/20 | 0.51 |
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | BUB1B | O60566 | 1/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | FES | P07332 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376247 | 0.91 | BRD4 (0.60) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL18376753 | 0.91 | PTK2 (0.56) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL29205091 | 0.90 | PTK2 (0.55) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL18376754 | 0.90 | PTK2 (0.54) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL18376833 | 0.88 | EGFR (0.56) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL18376775 | 0.85 | PTK2 (0.51) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL28697640 | 0.83 | PTK2 (0.51) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL18377065 | 0.83 | PTK2 (0.55) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL29368482 | 0.83 | PTK2 (0.55) | PTK2BRD4JAK2JAK3RET | |
| SCHEMBL28687781 | 0.82 | PTK2 (0.54) | PTK2BRD4JAK2JAK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |