Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 14/20 | 0.46 |
| ▸ | JAK2 | O60674 | 12/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376782 | 0.91 | JAK2 (0.49) | TBK1JAK3JAK2PTK2JAK1 | |
| SCHEMBL18376784 | 0.90 | TBK1 (0.49) | TBK1EGFRJAK3JAK2PTK2 | |
| SCHEMBL18376785 | 0.90 | TBK1 (0.48) | TBK1EGFRJAK3JAK2PTK2 | |
| SCHEMBL18377062 | 0.88 | JAK3 (0.56) | TBK1JAK3JAK2PTK2MAPK10 | |
| SCHEMBL18376831 | 0.88 | EGFR (0.56) | EGFRJAK3JAK2PTK2JAK1 | |
| SCHEMBL28695538 | 0.84 | TBK1 (0.49) | TBK1EGFRJAK3JAK2PTK2 | |
| SCHEMBL18376859 | 0.84 | JAK2 (0.49) | TBK1JAK3JAK2PTK2JAK1 | |
| SCHEMBL18376780 | 0.83 | TBK1 (0.49) | TBK1EGFRJAK3JAK2PTK2 | |
| SCHEMBL18376779 | 0.82 | TBK1 (0.50) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL18376853 | 0.80 | JAK3 (0.58) | TBK1JAK3JAK2PTK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |