Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376767 | 0.90 | TBK1 (0.49) | TBK1EGFRJAK3JAK2PTK2 | |
| SCHEMBL18376761 | 0.89 | EGFR (0.52) | EGFRJAK3JAK2PTK2JAK1 | |
| SCHEMBL18376757 | 0.88 | CDK1 (0.52) | TBK1JAK3JAK2PTK2CDK1 | |
| SCHEMBL18376781 | 0.88 | TBK1 (0.50) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL18376784 | 0.86 | TBK1 (0.49) | TBK1EGFRJAK3JAK2PTK2 | |
| SCHEMBL18376779 | 0.84 | TBK1 (0.50) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL28690545 | 0.82 | EGFR (0.54) | EGFRJAK3JAK2PTK2JAK1 | |
| SCHEMBL18376782 | 0.81 | JAK2 (0.49) | TBK1JAK3JAK2PTK2JAK1 | |
| SCHEMBL18376856 | 0.81 | JAK2 (0.51) | TBK1JAK3JAK2PTK2PCSK9 | |
| SCHEMBL18376780 | 0.80 | TBK1 (0.49) | TBK1EGFRJAK3JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |