Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | JAK2 | O60674 | 10/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28673294 | 0.88 | JAK3 (0.51) | TBK1JAK3JAK2MAPK10TYK2 | |
| SCHEMBL28689804 | 0.88 | EGFR (0.56) | EGFRJAK3JAK2JAK1FGFR2 | |
| SCHEMBL18376767 | 0.84 | TBK1 (0.49) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL18376784 | 0.83 | TBK1 (0.49) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL18376780 | 0.82 | TBK1 (0.49) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL18376779 | 0.81 | TBK1 (0.50) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL28120634 | 0.80 | CDK1 (0.53) | TBK1JAK3JAK2MAPK10TYK2 | |
| SCHEMBL28674130 | 0.80 | CDK1 (0.54) | TBK1JAK3JAK2MAPK10TYK2 | |
| SCHEMBL18376781 | 0.79 | TBK1 (0.50) | TBK1EGFRJAK3JAK2JAK1 | |
| SCHEMBL28686752 | 0.79 | EGFR (0.53) | EGFRJAK3JAK2JAK1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |