Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 8/20 | 0.50 |
| ▸ | JAK2 | O60674 | 7/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 2/20 | 0.46 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377058 | 0.93 | JAK2 (0.59) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376856 | 0.91 | JAK2 (0.51) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376781 | 0.90 | TBK1 (0.50) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376849 | 0.88 | JAK2 (0.61) | JAK3JAK2TBK1MAPK10MARK3 | |
| SCHEMBL18376757 | 0.86 | CDK1 (0.52) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376759 | 0.85 | MAPK10 (0.53) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376855 | 0.84 | JAK2 (0.58) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376779 | 0.83 | TBK1 (0.50) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL28120634 | 0.82 | CDK1 (0.53) | CDK1KDRJAK3JAK2TBK1 | |
| SCHEMBL18376762 | 0.81 | JAK2 (0.51) | KDRJAK3JAK2MAPK10PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |