Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PPOX | P50336 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842673 | 0.92 | PPARD (0.43) | HPGDSMN1; SMN2LMNAPPARDPTGDR | |
| SCHEMBL1840527 | 0.86 | ADRB3 (0.35) | HPGDPPOXESR1ALDH1A1KDM4E | |
| SCHEMBL1837083 | 0.84 | GAA (0.39) | SMN1; SMN2LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL1842508 | 0.84 | GLA (0.43) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1839136 | 0.83 | NR1H4 (0.40) | HPGDSMN1; SMN2LMNA | |
| SCHEMBL1842591 | 0.82 | NR1H4 (0.34) | HPGDSMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL1838536 | 0.82 | SMN1; SMN2 (0.38) | HPGDSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL1842633 | 0.81 | CYP2C9 (0.35) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1842335 | 0.81 | PPARA (0.47) | HPGDSMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL1841448 | 0.81 | PTGDR2 (0.38) | HPGDMEN1KMT2APTGDRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |