Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ATF4 | P18848 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841448 | 0.90 | PTGDR2 (0.38) | PTGDRPTGDR2ATF4ADAMTS4MMP8 | |
| SCHEMBL198628 | 0.87 | NR1H4 (0.38) | — | |
| SCHEMBL1840686 | 0.87 | CYP2C9 (0.37) | ATF4ALDH1A1LMNATP53 | |
| SCHEMBL1838591 | 0.86 | LMNA (0.32) | PTGDRPTGDR2KMT2AMEN1LMNA | |
| SCHEMBL1840672 | 0.85 | SMN1; SMN2 (0.40) | PTGDRPTGDR2ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1841265 | 0.85 | BACE1 (0.36) | — | |
| SCHEMBL1839025 | 0.85 | LMNA (0.32) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL198388 | 0.85 | PPARA (0.42) | ALDH1A1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL1837083 | 0.85 | GAA (0.39) | ALDH1A1SMN1; SMN2L3MBTL1KMT2ALMNA | |
| SCHEMBL1837772 | 0.84 | HPGD (0.38) | PTGDRPTGDR2ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |