Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838536 | 0.91 | SMN1; SMN2 (0.38) | GAASMN1; SMN2NPSR1S1PR1S1PR3 | |
| SCHEMBL1838605 | 0.90 | ALOX15 (0.37) | GAASMN1; SMN2NPSR1S1PR1S1PR3 | |
| SCHEMBL198628 | 0.89 | NR1H4 (0.38) | KCNH2 | |
| SCHEMBL1842633 | 0.87 | CYP2C9 (0.35) | LMNATP53ALDH1A1MAPTKMT2A | |
| SCHEMBL1842335 | 0.87 | PPARA (0.47) | SMN1; SMN2NPSR1LMNATP53ALDH1A1 | |
| SCHEMBL1841448 | 0.85 | PTGDR2 (0.38) | MAPTKMT2A | |
| SCHEMBL1842508 | 0.85 | GLA (0.43) | SMN1; SMN2LMNATP53ALDH1A1KMT2A | |
| SCHEMBL1837772 | 0.84 | HPGD (0.38) | SMN1; SMN2LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL1840672 | 0.84 | SMN1; SMN2 (0.40) | SMN1; SMN2NPSR1LMNATP53ALDH1A1 | |
| SCHEMBL1839025 | 0.83 | LMNA (0.32) | SMN1; SMN2NPSR1LMNATP53KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |