Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MDM4 | O15151 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837083 | 0.91 | GAA (0.39) | SMN1; SMN2L3MBTL1TP53LMNAFAAH | |
| SCHEMBL1839001 | 0.89 | NR4A2 (0.42) | SMN1; SMN2HPGDRAB9A | |
| SCHEMBL1838605 | 0.87 | ALOX15 (0.37) | SMN1; SMN2RAB9AL3MBTL1MDM2TP53 | |
| SCHEMBL1839730 | 0.86 | PPARA (0.41) | SMN1; SMN2HPGDRAB9AMDM4MDM2 | |
| SCHEMBL1838732 | 0.84 | FAAH (0.35) | MDM4MDM2TP53FAAHMGLL | |
| SCHEMBL1840762 | 0.82 | PPARA (0.40) | MAPT | |
| SCHEMBL1842335 | 0.82 | PPARA (0.47) | SMN1; SMN2HPGDTP53LMNAMAPT | |
| SCHEMBL1842633 | 0.82 | CYP2C9 (0.35) | TP53LMNAMAPTALDH1A1 | |
| SCHEMBL198628 | 0.81 | NR1H4 (0.38) | ENPP2 | |
| SCHEMBL1838591 | 0.81 | LMNA (0.32) | TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |