Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258383 | 0.94 | NPC1 (0.71) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL29817846 | 0.94 | NPC1 (0.71) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL3670066 | 0.89 | SMN1; SMN2 (0.72) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL148104 | 0.86 | MEN1 (0.78) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL22191811 | 0.83 | MEN1 (0.78) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL6027951 | 0.83 | MEN1 (0.88) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL30643220 | 0.83 | MEN1 (0.88) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL1811680 | 0.83 | L3MBTL1 (0.82) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL22574392 | 0.82 | MEN1 (0.59) | KMT2AMEN1KCNK3NPC1RAB9A | |
| SCHEMBL19156946 | 0.81 | KCNK3 (0.79) | KMT2AMEN1KCNK3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106132951-B | quinoline-based kinase inhibitors | 百时美施贵宝公司 | 2019-02-12 | — | — | CN | disclosed |
| EP-3099673-B1 | QUINOLINE-BASED KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-09-26 | — | — | EP | disclosed |
| US-9932320-B2 | Quinoline-based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160332985-A1 | Quinoline-Based Kinase Inhibitors | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2016-11-17 | — | — | US | disclosed |
| CN-106132951-A | Quinoline-based kinase inhibitors | 百时美施贵宝公司 | 2016-11-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332985-A1 | Quinoline-Based Kinase Inhibitors | AAK1, EEF2K, ADCK1 | KMT2A 2221/4885MEN1 4189/4885KCNK3 1275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.