SCHEMBL18387536

SCHEMBL18387536

Oc1cccc2nc3ccc(Br)cc3nc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.67
KMT2A Q03164 3/20 0.67
ALDH1A1 P00352 3/20 0.67
RAB9A P51151 2/20 0.67
GAA P10253 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
ACHE P22303 1/20 0.62
NQO2 P16083 7/20 0.62
MYC P01106 1/20 0.42
MAX P61244 1/20 0.42
PIK3R1 P27986 1/20 0.41
PIK3CA P42336 1/20 0.41
SAE1 Q9UBE0 1/20 0.40
UBA2 Q9UBT2 1/20 0.40
CYP1A2 P05177 1/20 0.40
PIM1 P11309 1/20 0.40
PIM2 Q9P1W9 1/20 0.40
MEN1 O00255 2/20 0.40
POLB P06746 1/20 0.40
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18387365 0.84 ACHE (0.69) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL3728001 0.82 ALDH1A1 (0.71) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL3244933 0.82 ALDH1A1 (0.71) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL28667228 0.82 NQO2 (0.59) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL31011404 0.82 ALDH1A1 (0.71) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL24276707 0.82 NQO2 (0.59) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL31260124 0.82 NQO2 (0.59) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL345562 0.81 ALDH1A1 (1.00) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL13872598 0.80 ACHE (0.58) MAPTKMT2AALDH1A1RAB9AGAA
SCHEMBL23612607 0.79 NQO2 (0.72) MAPTKMT2AALDH1A1RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180312473-A1 PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2018-11-01 US disclosed
WO-2017011730-A2 PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2017-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180312473-A1 PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS ROS1, NOX4, NOX5 MAPT 2461/4885KMT2A 3733/4885ALDH1A1 378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.