Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 12/20 | 0.46 |
| ▸ | SRC | P12931 | 6/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986327 | 0.84 | FGFR1 (0.46) | FGFR1SRCEGFRABL1TLR7 | |
| SCHEMBL16287646 | 0.78 | NPC1 (0.45) | FGFR1SRCEGFRABL1KDM4E | |
| SCHEMBL16986359 | 0.78 | DHFR (0.41) | FGFR1SRCEGFRKDRFGFR2 | |
| SCHEMBL16986308 | 0.68 | FGFR1 (0.39) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL4739652 | 0.65 | APP (0.45) | KDM4EMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL16986338 | 0.65 | NPC1 (0.46) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL16986344 | 0.65 | ADRB2 (0.48) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL16986341 | 0.64 | FGFR1 (0.57) | FGFR1SRCEGFRABL1FGFR2 | |
| SCHEMBL16986333 | 0.64 | TLR8 (0.41) | TLR7MAPTHTT | |
| SCHEMBL23260499 | 0.63 | NPY5R (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3120851-A1 | 4-AMINO-6-(2,6-DICHLOROPHENYL)-8-METHYL-2-(PHENYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE FOR TREATMENT OF SOLID CANCERS | Pangaea Biotech S.L. (ES) | 2017-01-25 | — | — | EP | disclosed |