Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.62 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27583094 | 0.98 | HPGDS (0.61) | HPGDSHTR4NPC1RAB9AKMT2A | |
| SCHEMBL24322445 | 0.91 | MAPK1 (0.55) | HPGDSHTR4NPC1RAB9AKMT2A | |
| SCHEMBL2536771 | 0.89 | NPC1 (0.64) | HPGDSNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11303306 | 0.89 | NPC1 (0.59) | HPGDSHTR4NPC1RAB9AKMT2A | |
| SCHEMBL11240479 | 0.84 | RAB9A (0.76) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL11813023 | 0.83 | HPGDS (0.62) | HPGDSNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL29530916 | 0.83 | ALDH1A1 (0.63) | HPGDSHTR4NPC1RAB9AKMT2A | |
| SCHEMBL1711687 | 0.83 | ALDH1A1 (0.63) | HPGDSHTR4NPC1RAB9AKMT2A | |
| SCHEMBL28324081 | 0.83 | MAPK1 (0.67) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL16789648 | 0.83 | MAPK1 (0.67) | NPC1RAB9AKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127912-B1 | TRIPEPTIDE EPOXYKETONE COMPOUND CONSTRUCTED BY HETEROCYCLE AND PREPARATION METHOD AND USE THEREOF | UNIV ZHEJIANG (CN) | 2021-04-21 | — | — | EP | disclosed |
| CN-107226808-B | Tankyrase inhibitors | 北京四环制药有限公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-104945470-B | Tripeptide epoxy ketone compound constructed by heterocycle, preparation and application | 浙江大学 | 2020-08-11 | — | — | CN | disclosed |
| US-9856288-B2 | Tripeptide epoxyketone compound constructed by heterocycle and preparation method and use thereof | ZHEJIANG UNIVERSITY (CN) | 2018-01-02 | — | — | US | disclosed |
| EP-3127912-A1 | TRIPEPTIDE EPOXYKETONE COMPOUND CONSTRUCTED BY HETEROCYCLE AND PREPARATION METHOD AND USE THEREOF | Zhejiang University (CN) | 2017-02-08 | — | — | EP | disclosed |
| US-20170022250-A1 | TRIPEPTIDE EPOXYKETONE COMPOUND CONSTRUCTED BY HETEROCYCLE AND PREPARATION METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA , CHINESE ACADEMY OF SCIENCES (CN) | 2017-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022250-A1 | TRIPEPTIDE EPOXYKETONE COMPOUND CONSTRUCTED BY HETEROCYCLE AND PREPARATION METHOD AND USE THEREOF | VIP, DNPEP, PREP | HPGDS 246/4885HTR4 3195/4885NPC1 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.