Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27973605 | 0.79 | LOXL2 (0.35) | OPRL1 | |
| SCHEMBL25252180 | 0.74 | OPRL1 (0.33) | OPRL1HDAC4PDE10A | |
| SCHEMBL12523394 | 0.74 | PDE8B (0.36) | OPRL1HDAC4PDE10A | |
| SCHEMBL23094533 | 0.74 | PDE10A (0.34) | OPRL1HDAC4PDE10A | |
| SCHEMBL10357425 | 0.71 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL12333863 | 0.71 | CTSK (0.42) | — | |
| SCHEMBL587475 | 0.70 | HDAC4 (0.38) | OPRL1HDAC4PDE10A | |
| SCHEMBL10581134 | 0.70 | OPRL1 (0.38) | OPRL1 | |
| SCHEMBL10716288 | 0.70 | SPHK1 (0.41) | TDP1 | |
| SCHEMBL10692937 | 0.70 | SPHK1 (0.41) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325471-A1 | COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS | Genzyme Corporation (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017015267-A1 | COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS | GENZYME CORPORATION (US) | 2017-01-26 | — | — | WO | disclosed |