Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.56 |
| ▸ | RXRB | P28702 | 1/20 | 0.56 |
| ▸ | RXRG | P48443 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30151185 | 1.00 | RXRA (0.56) | RXRARXRBRXRGHCAR3ALDH1A1 | |
| SCHEMBL19328918 | 0.90 | RXRA (0.52) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL20271725 | 0.90 | RXRA (0.65) | RXRARXRBRXRGHCAR3ALDH1A1 | |
| SCHEMBL29518728 | 0.90 | RXRA (0.65) | RXRARXRBRXRGHCAR3ALDH1A1 | |
| SCHEMBL24900263 | 0.88 | RXRA (0.50) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL31191358 | 0.87 | RXRA (0.49) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL30050315 | 0.84 | RXRA (0.53) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL18399121 | 0.84 | RXRA (0.53) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL7419168 | 0.84 | HCAR3 (0.56) | HCAR3ALDH1A1KHKL3MBTL1HSD17B10 | |
| SCHEMBL31191317 | 0.83 | RXRA (0.46) | RXRARXRBRXRGALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715292-A | 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-24 | — | — | CN | disclosed |
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |