Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | KHK | P50053 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PDE9A | O76083 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30040860 | 0.94 | HCAR3 (0.54) | HCAR3L3MBTL1HSD17B10GAAHTR1A | |
| SCHEMBL31403532 | 0.86 | HCAR3 (0.59) | HCAR3L3MBTL1HSD17B10GAAHTR1A | |
| SCHEMBL7971124 | 0.85 | ALDH1A1 (0.50) | HCAR3L3MBTL1HSD17B10HTR1AHTR1B | |
| SCHEMBL29491524 | 0.84 | KHK (0.43) | HCAR3L3MBTL1HSD17B10GAAHTR1A | |
| SCHEMBL18399007 | 0.84 | RXRA (0.56) | HCAR3L3MBTL1HSD17B10GAAHTR1A | |
| SCHEMBL30151185 | 0.84 | RXRA (0.56) | HCAR3L3MBTL1HSD17B10GAAHTR1A | |
| SCHEMBL18554576 | 0.82 | HCAR3 (0.57) | HCAR3L3MBTL1HSD17B10GAAHTR1A | |
| SCHEMBL3605908 | 0.80 | HTR1A (0.44) | HCAR3HTR1AHTR1BHTR1FALDH1A1 | |
| SCHEMBL3605904 | 0.79 | HTR1A (0.46) | HTR1AHTR1BHTR1FKHKALDH1A1 | |
| SCHEMBL30040346 | 0.79 | HTR1A (0.50) | HSD17B10GAAHTR1AHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |
| EP-0931075-A1 | INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER INC. (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998009961-A1 | INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER INC. (US) | 1998-03-12 | — | — | WO | disclosed |