Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21796618 | 1.00 | PDE4B (0.41) | PDE4BJAK2JAK3PTK2GPR119 | |
| SCHEMBL28615478 | 1.00 | PDE4B (0.41) | PDE4BJAK2JAK3PTK2GPR119 | |
| SCHEMBL18399048 | 0.91 | PDE4B (0.41) | PDE4BGPR119CCNKCDK12RXRA | |
| SCHEMBL18399278 | 0.91 | PDE4B (0.41) | PDE4BGPR119CCNKCDK12RXRA | |
| SCHEMBL28615466 | 0.91 | PDE4B (0.41) | PDE4BGPR119CCNKCDK12RXRA | |
| SCHEMBL21796776 | 0.87 | RXRA (0.46) | PDE4BRXRARXRBRXRGTP53 | |
| SCHEMBL21796615 | 0.86 | GPR119 (0.40) | PDE4BJAK2JAK3PTK2GPR119 | |
| SCHEMBL22723340 | 0.86 | GPR119 (0.40) | PDE4BJAK2JAK3PTK2GPR119 | |
| SCHEMBL18399288 | 0.86 | TRPV3 (0.41) | JAK2JAK3PTK2GPR119CCNK | |
| SCHEMBL21796877 | 0.86 | TRPV3 (0.41) | JAK2JAK3PTK2GPR119CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |