Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842245 | 0.90 | NR4A2 (0.40) | SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1840285 | 0.87 | NR1H4 (0.41) | MDM2SMN1; SMN2KMT2AGAACYP3A4 | |
| SCHEMBL1840826 | 0.86 | ACKR3 (0.34) | MDM2SMN1; SMN2KMT2AGAAMEN1 | |
| SCHEMBL1842553 | 0.86 | MDM2 (0.33) | MAPTMDM2SMN1; SMN2KMT2AGAA | |
| SCHEMBL1837083 | 0.82 | GAA (0.39) | MAPTSMN1; SMN2KMT2AGAAALDH1A1 | |
| SCHEMBL1840310 | 0.80 | NR1H4 (0.36) | MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL198628 | 0.80 | NR1H4 (0.38) | CYP3A4 | |
| SCHEMBL1839912 | 0.80 | NR1H4 (0.33) | MAPTSMN1; SMN2KMT2AGAAMEN1 | |
| SCHEMBL1842508 | 0.80 | GLA (0.43) | SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1843050 | 0.80 | NR1H4 (0.33) | MAPTSMN1; SMN2KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321282-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010028981-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-18 | — | — | WO | disclosed |