Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 6/20 | 0.54 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.54 |
| ▸ | SAT1 | P21673 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844968 | 0.86 | GNAO1 (0.46) | GNAO1GNAI3GNAI1SAT1CYP2C19 | |
| SCHEMBL23099440 | 0.84 | SAT1 (0.57) | GNAO1GNAI3GNAI1SAT1CYP2C19 | |
| SCHEMBL12524730 | 0.83 | GNAO1 (0.45) | GNAO1GNAI3GNAI1SAT1CYP2C19 | |
| SCHEMBL23810261 | 0.82 | SIGMAR1 (0.59) | SAT1CYP2C19CYP1A2SIGMAR1MEN1 | |
| SCHEMBL3865144 | 0.80 | SIGMAR1 (0.62) | SAT1CYP2C19CYP1A2SIGMAR1MEN1 | |
| SCHEMBL16312413 | 0.80 | SIGMAR1 (0.62) | GNAO1GNAI3GNAI1NAMPTSIGMAR1 | |
| SCHEMBL10042159 | 0.80 | MAPT (0.40) | GNAO1GNAI3GNAI1SAT1NAMPT | |
| SCHEMBL5963079 | 0.79 | GNAO1 (0.52) | GNAO1GNAI3GNAI1NAMPTITGB3 | |
| SCHEMBL28106413 | 0.79 | — | — | |
| SCHEMBL331124 | 0.78 | HRH3 (0.47) | GNAO1GNAI3GNAI1CYP1A2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549983-B2 | Amine cationic lipids and uses thereof | DICERNA PHARMACEUTICALS, INC. (US) | 2017-01-24 | — | — | US | disclosed |