Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | CALML3 | P27482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SDHA | P31040 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21555913 | 0.89 | MAOA (0.39) | MAOAMCHR1MAOBCALML3LMNA | |
| SCHEMBL1394095 | 0.84 | MAOA (0.57) | MAOAMAOBCALML3LMNAPTGS1 | |
| SCHEMBL17760907 | 0.83 | MAOA (0.46) | MAOAMCHR1MAOBCALML3LMNA | |
| SCHEMBL18403035 | 0.81 | MAOA (0.41) | MAOAMAOBCALML3LMNAPTGS1 | |
| SCHEMBL21555906 | 0.81 | MAOA (0.40) | MAOAMAOBCALML3LMNAPTGS1 | |
| SCHEMBL21555918 | 0.78 | MAOA (0.39) | MAOAMAOBCALML3LMNAPTGS1 | |
| SCHEMBL21555902 | 0.77 | L3MBTL1 (0.41) | MAOACALML3LMNA | |
| SCHEMBL18403006 | 0.77 | ATM (0.39) | MAOAMAOBCALML3LMNAPTGS1 | |
| SCHEMBL18402996 | 0.76 | MAOA (0.42) | MAOAMAOBCALML3LMNAPTGS1 | |
| SCHEMBL1393486 | 0.76 | MAOA (0.53) | MAOAMAOBCALML3LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550783-B2 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2017-01-24 | — | — | US | disclosed |