Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CALML3 | P27482 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SDHA | P31040 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21555918 | 0.89 | MAOA (0.39) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL1393379 | 0.84 | MAOA (0.56) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL21555917 | 0.82 | MAOA (0.38) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL21555920 | 0.82 | MAOA (0.40) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL21555905 | 0.81 | MAOA (0.40) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL21555919 | 0.80 | MAOA (0.41) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL21555902 | 0.80 | L3MBTL1 (0.41) | MAOALMNACALML3F10ALDH1A1 | |
| SCHEMBL21555913 | 0.78 | MAOA (0.39) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL21555906 | 0.77 | MAOA (0.40) | MAOALMNAMAOBCALML3PTGS1 | |
| SCHEMBL18402993 | 0.77 | MAOA (0.38) | MAOALMNAMAOBCALML3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550783-B2 | Biaryl heterocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2017-01-24 | — | — | US | disclosed |