Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | HPN | P05981 | 1/20 | 0.32 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763979 | 0.91 | PDK4 (0.42) | PTGDR2LNPEPBTK | |
| SCHEMBL1763543 | 0.74 | ADH5 (0.41) | MMP2MMP3MAPTTRPV1PPARG | |
| SCHEMBL1840656 | 0.72 | NOTUM (0.44) | MMP2MMP3MAPTTRPV1 | |
| SCHEMBL2040083 | 0.70 | PTGDR2 (0.54) | PTGDR2LNPEP | |
| SCHEMBL1763851 | 0.70 | SLC9A1 (0.45) | — | |
| SCHEMBL28909629 | 0.70 | TSHR (0.46) | MMP2MMP3MAPTMTORTRPV1 | |
| SCHEMBL3325476 | 0.70 | MAPT (0.50) | MMP2MMP3JAK1MAPTTRPV1 | |
| SCHEMBL23777377 | 0.70 | KMT2A (0.50) | MAPT | |
| SCHEMBL2037929 | 0.69 | PTGDR2 (0.54) | PTGDR2LNPEP | |
| SCHEMBL1763602 | 0.69 | P2RX7 (0.39) | PTGDR2MMP2MMP3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321274-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010005783-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |