Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | IDE | P14735 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ARG1 | P05089 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18395509 | 0.99 | ALDH1A1 (0.50) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| SCHEMBL18407260 | 0.88 | KDM4E (0.49) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL18395771 | 0.87 | KDM4E (0.48) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| SCHEMBL4929067 | 0.85 | ALDH1A1 (0.52) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| SCHEMBL4929082 | 0.85 | ALDH1A1 (0.52) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| SCHEMBL5283128 | 0.83 | ALDH1A1 (0.46) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| SCHEMBL6037979 | 0.83 | ALDH1A1 (0.46) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| 1-Methyltryptophan SCHEMBL19992 | 0.83 | MAPT (0.71) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| Indoximod SCHEMBL29349777 | 0.83 | MAPT (0.71) | ALDH1A1MAPTRECQLKDM4EMEN1 | |
| 1-Methyltryptophan SCHEMBL14202956 | 0.83 | MAPT (0.71) | ALDH1A1MAPTRECQLKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134658-A1 | SALTS AND PRODRUGS OF 1-METHYL-D-TRYPTOPHAN | LUMOS PHARMA, INC. | 2018-05-17 | — | — | US | disclosed |
| US-9732035-B2 | Salts and prodrugs of 1-methyl-D-tryptophan | NEWLINK GENETICS CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170022157-A1 | SALTS AND PRODRUGS OF 1-METHYL-D-TRYPTOPHAN | LUMOS PHARMA, INC. | 2017-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022157-A1 | SALTS AND PRODRUGS OF 1-METHYL-D-TRYPTOPHAN | IDO1, IDO2, INMT | ALDH1A1 634/4885MAPT 2135/4885RECQL 2301/4885 |
| US-20180134658-A1 | SALTS AND PRODRUGS OF 1-METHYL-D-TRYPTOPHAN | IDO1, IDO2, INMT | ALDH1A1 634/4885MAPT 2135/4885RECQL 2301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.