Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 13/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332506 | 1.00 | TGFBR1 (0.47) | TGFBR1EPHX1ACHEMMEALDH1A1 | |
| SCHEMBL5765667 | 1.00 | TGFBR1 (0.47) | TGFBR1EPHX1ACHEMMEALDH1A1 | |
| SCHEMBL9854740 | 0.93 | EPHX1 (0.54) | TGFBR1EPHX1ACHE | |
| SCHEMBL8658518 | 0.93 | EPHX1 (0.54) | TGFBR1EPHX1ACHE | |
| SCHEMBL7769025 | 0.93 | EPHX1 (0.54) | TGFBR1EPHX1ACHE | |
| SCHEMBL7769026 | 0.93 | EPHX1 (0.54) | TGFBR1EPHX1ACHE | |
| SCHEMBL8657701 | 0.93 | EPHX1 (0.54) | TGFBR1EPHX1ACHE | |
| SCHEMBL12354490 | 0.89 | TGFBR1 (0.50) | TGFBR1ACHEMMEALDH1A1 | |
| SCHEMBL5426414 | 0.89 | ACE (0.42) | TGFBR1EPHX1ACHEMME | |
| SCHEMBL480292 | 0.88 | EPHX1 (0.46) | EPHX1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031801-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| US-9108902-B2 | Deuterated 2-amino-3-hydroxypropanoic acid derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| EP-2861604-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2015-04-22 | — | — | EP | disclosed |
| EP-2859009-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| US-20140221492-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2014-08-07 | — | — | US | disclosed |
| US-8704001-B2 | Deuterated 2-amino-3-hydroxypropanoic acid derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| WO-2013185103-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2013-12-12 | — | — | WO | disclosed |
| WO-2013185090-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2013-12-12 | — | — | WO | disclosed |
| US-20110251131-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2011-10-13 | — | — | US | disclosed |
| EP-2321272-A1 | ORGANIC COMPOUNDS | Nabriva Therapeutics AG (AT) | 2011-05-18 | — | — | EP | disclosed |
| EP-1807397-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006046039-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-05-04 | — | — | WO | disclosed |
| CN-1741801-A | Water-soluble anionic bacteriochlorophyll derivatives and uses thereof | YEDA RES & DEV (IL) | 2006-03-01 | — | — | CN | disclosed |
| EP-1567147-A2 | WATER-SOLUBLE ANIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND THEIR USES | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004045492-A2 | WATER-SOLUBLE ANIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND THEIR USES | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-06-03 | — | — | WO | disclosed |
| EP-1246826-A1 | CHLOROPHYLL AND BACTERIOCHLOROPHYLL ESTERS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001040232-A9 | CHLOROPHYLL AND BACTERIOCHLOROPHYLL ESTERS, AND THEIR PREPARATION | YEDA RES & DEV (IL) | 2002-09-12 | — | — | WO | disclosed |
| WO-2001040232-A1 | CHLOROPHYLL AND BACTERIOCHLOROPHYLL ESTERS, AND THEIR PREPARATION | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2001-06-07 | — | — | WO | disclosed |
| EP-0775140-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005203-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221492-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | GRIN3A, GRIK5, GRIN2A | TGFBR1 2280/4885EPHX1 1150/4885ACHE 3058/4885 |
| US-20110251131-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | GRIN3A, GRIK5, GRIN2A | TGFBR1 2280/4885EPHX1 1150/4885ACHE 3058/4885 |
| US-20160031801-A1 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES | GRIN3A, GRIK5, GRIN2A | TGFBR1 2280/4885EPHX1 1150/4885ACHE 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.