SCHEMBL480292

SCHEMBL480292

CCCCOC(=O)NC(CC)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.46
ACHE P22303 7/20 0.44
ALDH1A1 P00352 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
HPGD P15428 1/20 0.42
RAB9A P51151 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
ITGB3 P05106 1/20 0.42
ITGA2B P08514 1/20 0.42
ATM Q13315 1/20 0.41
MAPK1 P28482 1/20 0.41
CTSK P43235 1/20 0.41
HCAR2 Q8TDS4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL284168 1.00 EPHX1 (0.46) EPHX1ACHEALDH1A1SMN1; SMN2NPC1
SCHEMBL1077922 0.88 NOD1 (0.48) EPHX1ACHEITGB3ITGA2BCTSK
SCHEMBL284211 0.88 ITGB3 (0.46) EPHX1ACHEALDH1A1ITGB3ITGA2B
SCHEMBL3655323 0.88 ITGB3 (0.46) EPHX1ACHEALDH1A1ITGB3ITGA2B
SCHEMBL283288 0.88 ITGB3 (0.46) EPHX1ACHEALDH1A1ITGB3ITGA2B
SCHEMBL7382637 0.88 NOD1 (0.48) EPHX1ACHEITGB3ITGA2BCTSK
SCHEMBL5765667 0.88 TGFBR1 (0.47) EPHX1ACHEALDH1A1
SCHEMBL2332506 0.88 TGFBR1 (0.47) EPHX1ACHEALDH1A1
SCHEMBL1840799 0.88 TGFBR1 (0.47) EPHX1ACHEALDH1A1
SCHEMBL4592659 0.86 EPHX1 (0.43) EPHX1ACHEALDH1A1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113613722-A Novel imidazole-pyrazole derivatives 豪夫迈·罗氏有限公司 2021-11-05 CN disclosed
CN-103582644-A Novel phthalazinone-pyrrolopyrimidine carboxamide derivatives NYCOMED GMBH 2014-02-12 CN disclosed
EP-2673269-A1 HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2013-12-18 EP disclosed
WO-2012107465-A1 HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-08-16 WO disclosed
EP-1654231-B1 CONJUGATE COMPOUNDS AND METHODS FOR REDUCING THE RISK OF EPILEPTIC OCCURRENCE OR FOR TREATMENT OF SEIZURE DISORDERS DPHARM LTD (IL) 2012-02-01 EP disclosed
EP-2326653-A1 NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS Pierre Fabre Médicament (FR) 2011-06-01 EP disclosed
WO-2010020663-A1 NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS PIERRE FABRE MEDICAMENT (FR) 2010-02-25 WO disclosed
EP-1598067-B1 Carbamic acid compounds comprising an amide linkage for the treatment of malaria TOPOTARGET UK LTD (GB) 2009-05-06 EP disclosed
EP-1951686-A1 QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF Hanmi Pharm. Co., Ltd. (KR) 2008-08-06 EP disclosed
EP-1877383-A1 QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY Chroma Therapeutics Limited (GB) 2008-01-16 EP disclosed
EP-1569646-A2 PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2005-09-07 EP disclosed
WO-2004054974-A2 PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2004-07-01 WO disclosed
EP-1335898-A1 CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS Prolifix Limited (GB) 2003-08-20 EP disclosed
US-6459001-B1 Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them AVENTIS PHARMA S.A. (FR) 2002-10-01 US disclosed
WO-2002026696-A1 CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS PROLIFIX LIMITED (GB) 2002-04-04 WO disclosed
EP-1102762-A2 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS PFIZER INC. (US) 2001-05-30 EP disclosed
WO-2000008013-A2 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS PFIZER PHARMACEUTICALS INC. (JP) 2000-02-17 WO disclosed
EP-0290211-A1 Dihydropyridines Pfizer Limited (GB) 1988-11-09 EP disclosed
EP-0080695-B1 PHYSIOLOGICALLY ACTIVE SUBSTANCE FA-5859, ITS DERIVATIVE; THEIR PRODUCTION AND ANTIDIABETIC AGENTS CONTAINING SAID COMPOUNDS Takeda Chemical Industries, Ltd. (JP) 1985-04-17 EP disclosed
US-4216309-A BACTERICIDES ABBOTT LABORATORIES (US) 1980-08-05 US disclosed