SCHEMBL18408697

SCHEMBL18408697

CSc1cccc(Sc2ccccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.47
MAPT P10636 3/20 0.47
POLB P06746 2/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
TP53 P04637 1/20 0.47
MAPK1 P28482 1/20 0.47
HSD17B10 Q99714 1/20 0.47
HTR2C P28335 2/20 0.47
HTR6 P50406 1/20 0.47
HPGD P15428 2/20 0.44
GAA P10253 1/20 0.44
MAOA P21397 3/20 0.44
MAOB P27338 3/20 0.44
SLC6A4 P31645 1/20 0.42
KIF11 P52732 1/20 0.42
ALDH1A1 P00352 2/20 0.42
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
GRM4 Q14833 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28439021 0.93 NOTUM (0.42) SMN1; SMN2MAPTPOLBMEN1KMT2A
SCHEMBL26861180 0.91 ANXA2 (0.40) SMN1; SMN2MAPTPOLBMEN1KMT2A
SCHEMBL9557022 0.87 HTR2C (0.56) SMN1; SMN2MAPTMAPK1HSD17B10HTR2C
SCHEMBL3889754 0.87 HTR2C (0.56) SMN1; SMN2MAPTMAPK1HSD17B10HTR2C
SCHEMBL3894071 0.87 HTR2C (0.56) SMN1; SMN2MAPTMAPK1HSD17B10HTR2C
SCHEMBL3893269 0.87 HTR2C (0.56) SMN1; SMN2MAPTMAPK1HSD17B10HTR2C
SCHEMBL3903397 0.85 MAOA (0.56) SMN1; SMN2MAPTPOLBMAPK1HSD17B10
SCHEMBL3902722 0.85 MAOA (0.56) SMN1; SMN2MAPTPOLBMAPK1HSD17B10
SCHEMBL3904216 0.85 MAOA (0.56) SMN1; SMN2MAPTPOLBMAPK1HSD17B10
SCHEMBL3889262 0.85 MAOA (0.56) SMN1; SMN2MAPTPOLBMAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017015609-A1 PROCESS FOR PREPARING PRIDOPIDINE TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) 2017-01-26 WO disclosed
US-20170022158-A1 PROCESS FOR PREPARING PRIDOPIDINE TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) 2017-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170022158-A1 PROCESS FOR PREPARING PRIDOPIDINE PDE6D, QDPR, PDE4D SMN1; SMN2 1688/4885MAPT 2188/4885POLB 94/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.