Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409597 | 1.00 | RIPK1 (0.41) | RIPK1TSHRLMNABRD4PIK3CD | |
| SCHEMBL21111282 | 0.86 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL21111285 | 0.86 | RIPK1 (0.41) | RIPK1 | |
| SCHEMBL17312429 | 0.84 | KIF11 (0.40) | RIPK1 | |
| SCHEMBL17312431 | 0.84 | KIF11 (0.40) | RIPK1 | |
| SCHEMBL17312438 | 0.83 | HPGD (0.44) | TSHRHPGDGAA | |
| SCHEMBL17312435 | 0.83 | HPGD (0.44) | TSHRHPGDGAA | |
| SCHEMBL17312518 | 0.82 | RIPK1 (0.38) | RIPK1 | |
| SCHEMBL2236141 | 0.81 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL2236134 | 0.81 | RIPK1 (0.46) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556152-B2 | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-31 | — | — | US | disclosed |